Scientific Name: Vicugna pacos
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Artiodactyla-> Tylopoda-> Camelidae-> Vicugna
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0001 | 2021.04 | 10X Genomics | Frontal | Normal | 3583 | Link |
| Vthunter_0002 | 2021.04 | 10X Genomics | Liver | Normal | 10408 | Link |
| Vthunter_0003 | 2021.04 | 10X Genomics | Lung | Normal | 1430 | Link |
| Vthunter_0059 | 2021.04 | iDrop | PBMC | Normal | 793 | Link |
Featureplot of receptors
Expression: Ubiquitous expression in thyroid (RPKM 45.9), ovary (RPKM 36.3) and 24 other tissues
